A 2 ml vial contains 40 mg of gentamicin.
Therapeutic action of Gentamicina
Gentamicin is an antibiotic with broad spectrum bactericidal action of group aminoglicosides. It acts on gram-positive germs and gram-negative. The most important action is the action against Pseudomonas aeruginosa, Klebsiella spp, Enterobacter, Serratia, Escherichia coli, strains positive and negative Proteus grieve and less active on Salmonella, Shigella, Neisseria gonorrhaeae and staphylococci, including Staphylococcus aureus.
Gentamicin is indicated in the treatment of severe infections such as septicemia (including neonatal Sepsis), severe kidney infection complicated and recurrent infections of the lower respiratory tract, gastrointestinal tract infections (including peritonitele), Infections of the skin, bones, soft tissues (including burns), infections of central nervous system (including meningitele), other systemic infections caused by sensitive germs. Gentamicin is the elective drug in the treatment of severe bacterial infections caused by infectious agents that are unknown or unidentified (as initial therapy before obtaining results of susceptibility tests), Infections of the accompanying diseases that affect human resistance (leukemia, diabetes, corticosteroid therapy, etc.).
Gentamicin is contraindicated in individuals with known history of hypersensitivity to gentamicin or other component of its formula, hypersensitivity or myasthenia gravis. Gentamicina is also not recommended for severe toxic reactions to gentamicin or other aminoglicozide that can contraindicate the use of gentamicin because of cross-sensitivity of patients to drugs in this class.
Gentamicina Adverse reactions
Like other aminoglicozide, gentamicin injection is potentially nephrotoxic. Nefrotoxifiants risk is greater in patients receiving high doses or prolonged therapy (toxicity is associated with prolonged serum peak concentration greater than 10 g / ml and / or serum concentration higher minimum 2 g / ml).
Gentamicin, injection can be administered intramuscularly or intravenously. The recommended dosage and precautions for intramuscular and intravenous administration are the same and can be calculated based on patient body weight. Usual duration of treatment is 7 to 10 days. Therapy for longer duration is preferable to be periodically measured the maximum and minimum concentrations.
Gentamicin’s method of administration: intramuscular or intravenous administration. To prevent pneumonia, gentamicin applied by endothracheal instalations. It will use only clear and uncoloured solutions.
Gentamicin is used in treatments of short duration, usually in combination with beta-lactamins. In combination treatment is indicated for serious infections, it is short and is made with high doses. If uncomplicated infections, the sensitive plate, is administered 2 mg / kg / day in 2-3 intakes. If germs or moderate sensitivity if not see a rapid clinical improvement, the daily dose will be increased to 3 mg / kg. In case of serious infections can manage up to 5 ml / kg / day divided in 3-4 intakes. To see septicemii table. In the only outlet, gentamicin is given as a short infusion for 15 minutes, 50-100 ml of saline, otherwise the administration is in or i.v. Duration of treatment: 3 to 7 (10) days. Doses above manages poor people, women and obese men, the dose would be reduced by 15% (an average of 80 mg / day). The blood of aminoglicozidului be determined on day 2 was (not later than the day 3-a) levels, with fasting, gentamicin of <2 mcg / ml.
Maximum daily dose of gentamicin (mg), divided into 1-2 equal prize, for patients with septicemia.